In 2006, terrorists have unleashed the deadly X-Pox plague. Billionaire Tad Mikleszewski (TM), desperate to get into space at any cost, hitches a lift on Soyuz to the International Space Station, where he intends to work on an X-Pox cure. But an accident contaminates the module where TM is working, and astronaut Mark Koskinen must prevent the virus from spreading to the entire Station.